The Dope Doula

Substance Information Sheet

Lysergic acid amide (also known as ergine, d-lysergic acid amide, d-lysergamide)

LSA (lysergic acid amide) was first described in 1932 during research into ergot alkaloids. In 1947, Albert Hofmann synthesized and tested it, noting that a 500-microgram intramuscular dose induced a "tired, dreamy state with an inability to maintain clear thoughts." In 1970, LSA was identified in Hawaiian baby woodrose seeds, which were ground into capsules and sold as "mescaline." Today, LSA is commonly consumed via morning glory or Hawaiian baby woodrose seeds.

User reports describe the effects of LSA as mainly sedating and dream-like, with mild to moderate psychedelic effects. However, these effects are inconsistent and differ from those of classical psychedelics like LSD, psilocybin mushrooms, or mescaline. The psychedelic experience with LSA is often more bodily and cognitive, with minimal visual effects. Many users report significant nausea and physical discomfort ("body load") when consuming seeds containing LSA.

Although not considered addictive, LSA can cause adverse reactions like severe anxiety, paranoia, and psychosis, especially in individuals predisposed to psychiatric disorders, therefore familiarising yourself with LSA harm reduction practices are beneficial.

Class Membership

Psychoactive class - Psychedelic

Chemical class - Lysergamide

Dangerous combinations & interactions

LSA Harm Reduction - Interactions

Lithium: Often prescribed for bipolar disorder, lithium taken with psychedelics significantly raises the risk of psychosis and seizures. Therefore, this combination is strictly discouraged.

Cannabis: Cannabis can have an unexpectedly strong and unpredictable synergy with LSA, increasing the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users should begin with a small fraction of their normal cannabis dose and take long breaks between hits to prevent accidental overdose.

Stimulants: Stimulants like amphetamines, cocaine, or methylphenidate affect various brain regions and alter dopaminergic function. Mixing stimulants with LSA can heighten the risk of anxiety, paranoia, panic attacks, and thought loops, and may increase the likelihood of mania and psychosis.

Tramadol: Tramadol lowers the seizure threshold, and psychedelics may trigger seizures in susceptible individuals.

SSRIs: Selective serotonin reuptake inhibitors are reported to suppress LSA's visual and cognitive effects.

MAOIs: Monoamine oxidase inhibitors (like passionflower and Syrian rue) can amplify the visual and introspective effects of psychedelics. Caution should be taken when combining MAOIs with psychedelics, as this can increase the likelihood of a bad trip and may dangerously interact with other substances, such as SSRIs, stimulants, and certain psychedelics like MDA.

IMPORTANT SAFETY CONSIDERATIONS FOR LSA HARM REDUCTION

TOXICITY

The toxicity and long-term health effects of recreational LSA use have not been scientifically studied, and the precise toxic dose remains unknown. Anecdotal evidence indicates that using LSA by itself, in low to moderate doses and infrequently, doesn't seem to produce negative health effects, but this can't be guaranteed.

It's crucial to independently research any combination of substances to ensure their safety before consumption, particularly with substances like LSA, whose effects are not fully understood.

Vasoconstriction

The toxicity and long-term health effects of recreational LSA use have not been scientifically studied, and the exact toxic dose remains unknown. Anecdotal evidence suggests that using LSA alone, in low to moderate doses and sparingly, does not typically result in negative health effects, though this cannot be guaranteed.

It's essential to thoroughly research any combination of substances to ensure their safety before consumption, especially with substances like LSA, whose effects are not fully understood.

see “navigating psychedelic experiences” section

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DATURA

MOONFLOWER | DEVIL’S TRUMPET

Datura Safety Tips

Datura, also known by names like devil's trumpet, moonflower, jimsonweed, devil's weed, hell's bells, and thorn-apple, is a genus consisting of nine species of poisonous flowering plants in the Solanaceae family. Datura is known for its potent and dangerous deliriant properties, historically used for shamanic and medicinal purposes, as well as for poison. Its seeds and flowers contain potent anticholinergic substances like scopolamine, hyoscyamine, and atropine.

In some regions, the seeds are colloquially called "malpitte," which translates to "insanity seeds."

IMPORTANT SAFETY CONSIDERATIONS

TOXICITY

Datura, renowned for its highly erratic effects, poses significant risks including severe consequences such as hospitalization or even fatality. Despite its potential toxicity and long-term health implications, scientific inquiry into the regular use of datura remains scarce, largely due to its infrequent usage and the absence of established toxic dosage parameters. Traditional societies relied heavily on extensive familiarity and nuanced understanding of datura to mitigate harm effectively. However, contemporary incidents reveal a concerning trend of fatalities and severe illnesses among modern users, particularly adolescents and young adults, who deliberately consume datura. Notable cases documented in the United States media during the 1990s and 2000s underscore the dangers associated with its ingestion. Medical literature also recounts numerous fatalities resulting from intoxication with Datura stramonium and Datura ferox. Children, in particular, are highly susceptible to atropine poisoning, with grim prognoses often leading to fatal outcomes. Additionally, datura has historically served as a favoured agent for suicide and homicide in certain regions of Europe and India. For instance, between 1950 and 1965, the State Chemical Laboratories in Agra, India, recorded 2,778 deaths attributed to datura ingestion.

psychosis

Datura is associated with a notably elevated incidence of inducing psychosis and delirium compared to other hallucinogens such as LSD, ketamine, or DMT. Numerous online accounts recount episodes of psychotic delirium, amnesia, and various severe outcomes following the misuse of this substance. Often, these experiences lead to hospitalization or even fatalities.

lethal dosage

The potency of datura can vary significantly, with a potential 5:1 difference between individual plants. Factors such as the plant's age, location, and local climate further influence its toxicity, rendering datura exceptionally perilous as a substance. Given this variability, there is no reliable method for the layperson to accurately gauge the dosage of any given plant. Historically, datura has been utilized as a poison in certain cultures due to the presence of these potent compounds. To mitigate the risk of overdose, it is recommended to finely grind the dried plant material into a uniform powder, ensuring even distribution of its active chemicals. Gradually increasing the dosage in minute increments is advised until the appropriate amount for the specific plant is determined. However, it is strongly cautioned to refrain from using datura altogether. If one chooses to proceed, stringent harm reduction measures, such as having a sober and attentive trip sitter present throughout the experience, are essential.

tolerance and dependence potential

The potential for mild addiction and adverse effects, such as psychosis, is associated with the use of datura. However, it is considered less addictive compared to other substances, as the majority of individuals who experiment with it do not desire to repeat the experience. Continued usage of datura leads to the development of tolerance to many of its effects, necessitating progressively larger doses to achieve the same results. Following cessation of consumption, it typically takes 3 to 7 days for tolerance to diminish by half and 1 to 2 weeks to return to baseline levels. Moreover, datura induces cross-tolerance with other deliriants, meaning that subsequent consumption of deliriants will result in reduced effects.

salvia divinorum

Diviner's Sage, Ska María Pastora, Seer's Sage

Salvia Responsible Use

Salvia divinorum, a perennial plant indigenous to the Mazatec regions of Mexico's Sierra Madre Oriental Mountains, thrives in tropical forests at elevations ranging from 300 to 800 meters above sea level. Classified within the Lamiaceae family, it primarily propagates through cuttings due to its infrequent seed production.

The plant contains a highly potent psychoactive compound known as salvinorin A, which elicits psychedelic and dissociative effects even at very low doses. The duration of these effects varies depending on the method of ingestion, typically lasting between fifteen minutes and two hours. Salvinorin A stands as the most potent naturally occurring psychoactive substance identified to date.

class membership

Psychoactive class - Hallucinogen

Chemical class - Salvinorin

CLASSIFICATION

Presently, salvinorin A is categorized as a hallucinogen in scientific literature, although there exists ongoing debate regarding its classification as either a dissociative or an atypical dissociative, possessing some psychedelic and potentially delirious attributes.

While salvia induces hallucinatory experiences and out-of-body sensations commonly associated with typical dissociatives (specifically NMDA receptor antagonists), arguments suggest that these similarities are insufficient for it to be classified in the same category. For instance, the nature and complexity of the hallucinatory experiences on salvia differ significantly. Furthermore, the out-of-body sensations typically attributed to dissociatives are believed to stem from the inhibition of signals to the conscious mind by NMDA receptor antagonists. This results in a distinct sense of dissociation, disconnection, and detachment, which is not observed with salvia as it operates on a distinct set of receptors with largely unknown functions in the human brain.

Salvia's effects possess a unique subjective style and pharmacology not found in other hallucinogen categories. Consequently, many in the psychonaut community advocate for its recognition as belonging to a wholly new classification. Compounds within this subjective and pharmacological classification could potentially be termed "salviagenic," encompassing various analogues such as Salvinorin B and others.

CHEMICAL COMPOSITION AND DOSAGE

The leaves of Salvia divinorum contain two diterpenes called salvinorin A and salvinorin B (also known as divinorin A and divinorin B). They also contain other substances that are not clearly identified.

Salvinorin A is the most potent natural psychedelic substance known. It is about 10 times more potent than psilocybin. Its chemical formula is C23H28O8 and it does not contain nitrogen, so it is not an alkaloid. At the pharmacological level it acts as a selective agonist for kappa opioid receptors, which differentiates it from other psychedelic compounds that act mainly on the serotonergic system, specifically binding to the 5HT2A receptors. Salvinorin A is therefore quite an unusual compound.

Doses of salvinorin A that produce psychoactive effects start at 150 micrograms (or millionths of a gram). Common doses are between 150 and 500 micrograms.

Dried S. divinorum can be found on the market, although its availability in the form of extracts is more common. These extracts are more potent than dried leaves, so a much smaller amount is required to achieve psychoactive effects. Fresh leaves are usually only found in places where S. divinorum is grown and are not usually available in other markets.

The traditional route of administration is usually the chewing of fresh or dried leaves, as well as the ingestion of leaf infusions. In current contexts in the western world, the most common route of administration is the smoking of extracts.

An approximate summary of the usual doses is as follows:

Smoked or vaporized route. Dosage of leaves

Low dose: 0.25 grams
Average dose: 0.5 grams
High dose: 0.75 grams

Smoked or vaporized route. Dosage of 5x extract

Low dose: 0.05 – 0.1 g
Average dose: 0.08 – 0.15 g
High dose: 0.01 – 0.025

Smoked or vaporized route. Dosage of Pure Salvinorin A

Low dose: 75 – 100 μg (dose in micrograms, 1000 micrograms, ug = 1 milligram, mg)
Average dose: 200 – 400 ug
High dose: 400 – 500 ug

Sublingual/chewed route. Dosage of leaves

Low dose: 10 g of fresh leaves / 2 g of dried leaves
Average dose: 30 g of fresh leaves / 6 g of dry leaves
High dose: 50 g of fresh leaves / 10 g of dried leaves

Oral route: infusion of crushed leaves (in pairs of leaves, traditional use)

Low dose: less than 20 pairs (40 leaves)
Average dose: from 20 to 60 pairs
High dose: 60 to 80 pairs

NOTICE

The Dope Doula provides information solely for educational and harm reduction purposes. We do not promote, sell, or facilitate the sale of illegal substances on this website. It is important to note that we do not endorse or encourage using illegal compounds. We aim to provide accurate and balanced information on salvia responsible use, lsa harm reduction and provide these datura safety tips to promote safety, health, and responsible decision-making. Additional research is encouraged as the information here is extremely limited.

Even though the interactions of certain substances are described here, it is essential to be safe at all times! This article is only to give information about interactions and their effects, this article is NOT meant for advice on taking any combination!

Many interactions described here are subjective descriptions, so what is shown here is only an indication of how certain combinations can affect you and how safe they are. Many times those effects are dependent on the dose (of each substance), route of administration, timeline of administration, set and setting, mood, and physical health, Those effects often depend on mental health and many other factors.

LSA | datura | salvia

Substance Information Sheet

Lysergic acid amide (also known as ergine, d-lysergic acid amide, d-lysergamide)

Class Membership

Dangerous combinations & interactions

IMPORTANT SAFETY CONSIDERATIONS FOR LSA HARM REDUCTION

DATURA

MOONFLOWER | DEVIL’S TRUMPET

Class Membership

danger!

Extreme Caution

SEE THE “NAVIGATING PSYCHEDELICS EXPERIENCES” SECTION

IMPORTANT SAFETY CONSIDERATIONS

salvia divinorum

Diviner's Sage, Ska María Pastora, Seer's Sage

class membership

CLASSIFICATION

CHEMICAL COMPOSITION AND DOSAGE

Navigating PSYCHEDELIC EXPERIENCES

SET

SETTING

TRIP SITTERS

Special Thanks to

NOTICE

LSA | datura | salvia

Substance Information Sheet

Lysergic acid amide (also known as ergine, d-lysergic acid amide, d-lysergamide)

Class Membership

Dangerous combinations & interactions

IMPORTANT SAFETY CONSIDERATIONS FOR LSA HARM REDUCTION

DATURA

MOONFLOWER | DEVIL’S TRUMPET

Class Membership

danger!

Extreme Caution

SEE THE “NAVIGATING PSYCHEDELICS EXPERIENCES” SECTION

IMPORTANT SAFETY CONSIDERATIONS

salvia divinorum

Diviner's Sage, Ska María Pastora, Seer's Sage

class membership

CLASSIFICATION

CHEMICAL COMPOSITION AND DOSAGE

Navigating PSYCHEDELIC EXPERIENCES

SET

SETTING

TRIP SITTERS

Special Thanks to

NOTICE

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