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GHB | GBL

Substance Information Sheet

GHB

Gamma-Hydroxybutyric acid, also known as 4-hydroxybutanoic acid or GHB is a central nervous system depressant with effects somewhat like alcohol, Xanax, and MDMA. It appears in trace amounts in beer and wine, as well as in the human brain as a metabolite of the neurotransmitter GABA, which plays a role in regulating fear and anxiety.  GHB’s taste is often described as salty or soapy.


GBL (gamma butyrolactone) is a prodrug of GHB.  GBL has a “chemical, plastic taste".  GBL is often sold as GHB, but due to the difference in dosage, it’s important to know which one you are taking.


DOSAGE:

The dilution strength of GHB and GBL can vary even from the same source.  Kristin Karas, director of operations with DanceSafe, recommends starting with a dose no bigger than 1.5mL.

Wait a minimum of 2 hours before redosing.  If you want to increase your dose, titrate with only a 5% increase.

Use a syringe to measure doses accurately and set an alarm on your phone to ensure you don’t redose too quickly.


It takes about 30 minutes to feel a GHB dose and its most noticeable effects will last around two hours—though residual effects can continue for about four hours. 

GBL, on the other hand, can be felt in as little as 15 minutes and will also start to wear off more quickly—roughly between 60 and 90 minutes after the come up. 


SIDE EFFECTS:

Potential side effects, particularly from overdoing GHB or mixing it with other central nervous system depressants, include:

·      Vomiting

·      Slowed heart and breathing rates

·      Passing out or unresponsiveness

·      Amnesia (i.e. forgetting that the drug was taken and what happened while under the influence)

·      Sleeplessness (usually after a period of re-dosing)

·      Anxiety (on the come-down)

In cases of overdose or mixing with other depressants, it’s possible for GHB to cause convulsions, breathing cessation, coma, and even death. 


WITHDRAWAL:

It’s possible to experience withdrawals after a period of heavy and/or frequent GHB use. Common withdrawal symptoms include:

·      Anxiety

·      Paranoia

·      Tremors

·      Sleeplessness

·      Hallucinations, delusions, or psychosis

·      High blood pressure 

If you’re experiencing GHB withdrawals, seek help and avoid self-medicating to relieve symptoms. 

Class Membership

Psychoactive class - Depressant

Chemical class - Butyric Acid

CRITICAL WARNING

Extreme Caution

GHB is commonly used in party settings like nightclubs and festivals, and it is also recognized as a date rape drug. Combining GHB with alcohol can be fatal due to the risk of severe respiratory depression.


A study of 226 GHB-related deaths found that 71 (34%) were due to GHB alone, while the rest were caused by respiratory depression from the interaction of GHB with alcohol or other drugs.

dangerous combinations

GHB DRUG INTERACTIONS

We strongly recommend you avoid taking antihistamines and GHB together, reactions are highly unpredictable and can be fatal. You will likely come to some degree of harm even if you take strong precautions.


Alcohol and GHB is an unsafe combination. Even in very low doses this rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration while unconscious.


Be careful when mixing amphetamines and GHB. Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.


Be careful when taking GHB with MDMA. Large amounts of GHB/GBL may overwhelm the effects of MDMA on the comedown.


Benzos and GHB are an unsafe combination. The two substances potentiate each other strongly and unpredictably, rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position.


Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.


The sedative effects of this combination can lead to dangerous respiratory depression.


The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position.


Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. This combination is hard to predict.


GBL INFORMATION SHEET | ghb substance information

UK & IRELAND DRUG WATCH

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NOTICE

attention:

Please remember that harm reduction strategies should always be implemented in conjunction with advice and support from healthcare professionals or other qualified experts. If you are seeking assistance for a specific medical or psychological condition, it is essential to consult with a licensed professional for personalized guidance.


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