5-MEO-DMT

Substance Information Sheet

5-Methoxy-N,N-dimethyltryptamine

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring psychedelic compound in the tryptamine class. Structurally, it's related to DMT and 5-HO-DMT (bufotenin). Known for producing some of the most intense psychedelic experiences in its class, 5-MeO-DMT exerts its effects by binding to serotonin receptors in the brain, although the exact mechanism remains unclear.

Class Membership

Psychoactive class - Psychedelic

Chemical class - Tryptamine

Common Names

5-MeO-DMT, The God Molecule, Toad, Jaguar

DANGEROUS COMBINATIONS

INTERACTIONS

2C-T-X: This class of compounds can be unpredictable even when taken alone.

2C-X: The 5-MeO psychedelics can unpredictably interact with and enhance the effects of other psychedelics.

Cannabis: Cannabis may heighten the risk of adverse psychological effects such as anxiety, paranoia, and psychosis.

DOx: The 5-MeO tryptamines may lead to unpredictable interactions, increasing the likelihood of unpleasant physical side effects.

MDMA: Some 5-MeO tryptamines are unpredictable, so combining them with MDMA requires caution.

Mescaline: The 5-MeO tryptamines can interact unpredictably with mescaline.

NBOMe: Both NBOMes and 5-MeO tryptamines can be unpredictable on their own, making this combination potentially risky.

Amphetamines: The anxiogenic and focusing effects of stimulants heighten the chances of unpleasant thought loops. The combination is generally unnecessary due to the stimulating effects of psychedelics.

Cocaine: Similar to amphetamines, cocaine’s stimulating and focusing effects can increase the chance of unpleasant thought loops. It's typically unnecessary when combined with psychedelics due to their stimulating effects.

DXM: There's limited information available on this combination.

Tramadol: Mixing with tramadol increases the risk of serotonin syndrome.

aMT: The risk of serotonin syndrome is heightened with this combination.

MAOIs: Combining MAOIs with other substances significantly raises the risk of serotonin syndrome.

PCP: There's not much known about the combination of PCP and psychedelics, but it may increase the risk of psychosis and overstimulation.

IMPORTANT SAFETY CONSIDERATIONS

Psychosis and mental disorder risk

Toad can exacerbate symptoms (e.g. delusions, mania, psychosis) of various mental disorders. Additionally, they can precipitate the early onset of schizophrenia in vulnerable individuals.

Those with a personal or family history of mental disorders, particularly psychotic disorders like schizophrenia, should not use psilocybin mushrooms without consulting a qualified medical professional.

Stay Alive

Deaths involving 5-MeO-DMT are uncommon. However, because 5-MeO-DMT is a potent monoamine reuptake inhibitor (MRI), injuries can occur if excessive doses are taken or when it is combined with substances like MAOIs, RIMAs, stimulants, or other compounds that act as releasing agents or reuptake inhibitors of neurotransmitters such as serotonin and dopamine. These interactions have led to life-threatening poisonings and documented deaths that might have been preventable.

NOTICE

ATTENTION

The Dope Doula provides information solely for educational and harm reduction purposes. We do not promote, sell, or facilitate the sale of illegal substances on this website. It is important to note that we do not endorse or encourage the use of illegal compounds. Our aim is to provide accurate and balanced information to promote safety, health, and responsible decision-making.

While we acknowledge that substance use may occur despite legal prohibitions, we firmly advocate for personal well-being and safety. Our content is designed to raise awareness about potential risks and provide harm-reduction strategies for individuals who choose to use substances. We emphasize the importance of informed choices, consent, and responsible behaviour.

Many interactions described here are subjective descriptions, so what is shown here is only an indication on how certain combinations can affect you and how safe they are. Many times those effects are dependent on dose (of each substance), route of administration, timeline of administration, set and setting, your mood, your physical health, your mental health and many other factors.

5-MEO-DMT

Substance Information Sheet

5-Methoxy-N,N-dimethyltryptamine

Class Membership

Common Names

CRITICAL WARNING

WARNING: 5-MeO-DMT is not a valid substitute for DMT.

DANGEROUS COMBINATIONS

INTERACTIONS

FIVE AND FIRESIDE PROJECT’S GUIDE TO 5-MEO-DMT SAFETY PRACTI

IMPORTANT SAFETY CONSIDERATIONS

Navigating PSYCHEDELIC EXPERIENCES

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SETTING

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NOTICE

ATTENTION

5-MEO-DMT

Substance Information Sheet

5-Methoxy-N,N-dimethyltryptamine

Class Membership

Common Names

CRITICAL WARNING

WARNING: 5-MeO-DMT is not a valid substitute for DMT.

DANGEROUS COMBINATIONS

INTERACTIONS

FIVE AND FIRESIDE PROJECT’S GUIDE TO 5-MEO-DMT SAFETY PRACTI

IMPORTANT SAFETY CONSIDERATIONS

Navigating PSYCHEDELIC EXPERIENCES

SET

SETTING

TRIP SITTERS

for more info

visit

Special Thanks to

NOTICE

ATTENTION

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