THE DOPE DOULA

Substance Information Sheet

DMT

N, N-Dimethyltryptamine (often called DMT, N, N-DMT, Dmitri, or "The Spirit Molecule") is a classical psychedelic in the tryptamine class. It's recognized for producing short-lived but intense visionary states and vivid hallucinations. Although the precise mechanism isn't fully understood, DMT is thought to exert its effects by binding to serotonin receptors in the brain.

DMT is a potent substance
with visionary effects. It is administered intravenously or vaporized. DMT crystals are not orally active because it is degraded by the MAO present in the stomach and liver.
There are more than 50 known plants that contain DMT in varying amounts and it is possible that it is also found in the nervous system of mammals, including the human brain.

DMT dosage oral administration (in combination with harmalines)

The dose range of DMT in the presence of harmalines or other MAO inhibitors varies from 0.5mg/kg to 1mg/kg. So, for a person weighing 70kg the doses would be the following:

» Threshold dose: 30mg » Average dose: 50mg
» High dose: 70mgDMT is generally

DMT is similar in structure to melatonin (a hormone that regulates the sleep–wake cycle) and serotonin (a monoamine neurotransmitter that contributes to feelings of well-being and happiness) and occurs naturally in all mammals in minute quantities. It’s unique in that tolerance doesn’t seem to build up with use.

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Class Membership

Psychoactive class - Psychedelic

Chemical class - Tryptamine

WHAT TO EXPECT

PROGRESSIVE STAGES

When smoked or vaporized at moderate to heavy dosages, the DMT experience consistently manifests itself in a progressive sequence which can be described as follows:

BREAKING THROUGH

The initial phase of a DMT trip, known as the "come-up," often leads to an experience commonly called "breaking through," which can manifest in various ways. Initially, users notice distinctive visual enhancements, including heightened visual acuity and intensified colors. This phase is quickly followed by the appearance of high-level geometric patterns (level 3 geometry) that become progressively intense, enveloping and obscuring the surrounding environment.

Auditory hallucinations frequently accompany these visuals, manifesting as soft crackling sounds or high-pitched, extended tones. Additionally, physical sensations often arise during the "breakthrough" phase, including the feeling of being pushed through a membrane or of shooting through space at high speeds.

THE WAITING ROOM

After inhaling enough DMT to "break through," users often find themselves in what some describe as a psychedelic "waiting room" or "loading screen." This space varies widely in appearance but is typically perceived as a surrounding tunnel composed of rapidly shifting, interlocking geometric patterns. This stage lasts around 10 to 20 seconds and feels distinctly different from other parts of the DMT experience.

THE OTHER SIDE

After the "waiting room" phase ends, users typically feel that they've "broken through" to the other side. At this point, intense level 7 geometric patterns and level 3 to 4 internal hallucinations are experienced. While each individual's experience is unique, many DMT trips follow common archetypes, scenarios, and plots. These often involve visiting what seems like an alternate reality with autonomous entities, unique settings, landscapes, and themes of a cosmic, transcendental, or transpersonal nature.

DRIFTING DOWN

In the final stage of a DMT trip, users feel as though they're being gradually pulled away from the scenario until it's no longer visible, at which point they return to reality. This phase is typically accompanied by level 3 to 4 geometric visuals and a strong sense of exhilaration and awe. Moderate to mild geometric patterns may linger for another 10 to 15 minutes before fading away completely, sometimes leaving a noticeable "body high" that can persist for up to an hour.

DMT drug interactions

Mixing DMT and other drugs

Lithium

Often prescribed for bipolar disorder, lithium taken with psychedelics can significantly increase the risk of psychosis and seizures. This combination is strictly discouraged due to extensive anecdotal evidence.

Cannabis

Cannabis can have a strong, unpredictable synergy with DMT. Caution is advised, as this combination may significantly raise the risk of adverse psychological reactions such as anxiety, paranoia, panic attacks, and psychosis. Users should begin with a fraction of their usual cannabis dose and take extended breaks between hits to prevent accidental overdose.

stimulants

Substances like amphetamines, cocaine, or methylphenidate affect brain regions and dopaminergic function. Combining stimulants with DMT can heighten the risk of anxiety, paranoia, panic attacks, thought loops, mania, and psychosis.

Tramadol

Tramadol lowers the seizure threshold, and psychedelics may trigger seizures in susceptible individuals.

Modafinil

We strongly recommend you avoid taking these drugs together, reactions are highly unpredictable and can be fatal.

2CB

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Be careful when mixing these drugs. Effects will compound with each other, however, the effects of DMT will probably overpowerful

NOTICE

WARNING

The Dope Doula provides information solely for educational and harm reduction purposes. We do not promote, sell, or facilitate the sale of illegal substances on this website. It is important to note that we do not endorse or encourage using illegal compounds. We aim to provide accurate and balanced information to promote safety, health, and responsible decision-making.

While we acknowledge that substance use may occur despite legal prohibitions, we firmly advocate for personal well-being and safety. Our content is designed to raise awareness about potential risks and provide harm-reduction strategies for individuals who choose to use substances. We emphasize the importance of informed choices, consent, and responsible behaviour.

Even though the interactions of certain substances are described here, it is essential to be safe at all times! This article is only to give information about interactions and their effects, this article is NOT meant for advice on taking any combination!

Many interactions described here are subjective descriptions, so what is shown here is only an indication of how certain combinations can affect you and how safe they are. Many times those effects are dependent on the dose (of each substance), route of administration, timeline of administration, set and setting, mood, and physical health, Those effects often depend on mental health and many other factors.

DMT