The Dope Doula

Substance Information Sheet

Novel Psychedelics

Substituted dimethoxyphenethylamines, known as 2C-x, or 2c research chemical refer to a family of psychedelic phenethylamines first researched by Alexander Shulgin. During the 1970s, Shulgin synthesized many of the 2C-x compounds and documented his research in his book "PiHKAL." He coined the term "2C" as an abbreviation for the two carbon atoms that separate the benzene ring from the amino group. The effects of 2C-x compounds range from completely inactive to intensely psychedelic. Popular chemicals in this group include 2C-B, 2C-E, and 2C-I.

4-Bromo-2,5-dimethoxyphenethylamine, also known as Nexus, Bromo Mescaline, BDMPEA, Venus, or 2C-B, is a psychedelic substance within the phenethylamine class. It's the most well-known member of the 2C-x family, sharing a structural relationship with the classic psychedelic mescaline. Although the exact mechanism of action is not fully understood, it is believed that serotonin receptor activity is primarily involved.

Class Membership

Psychoactive class - Novel Psychedelic

Chemical class - Phenethylamine

ROUTES OF ADMINISTRATION

Oral:

Ingestion - swallowing it

Gumming - rubbed onto gums with a fingertip

Insufflation:

Cut into lines and snorted - reported to be extremely painful and results in a much faster onset and a shorter total duration.

Smoking:

Some reports of smoking, however reported effects vary from no effect to negative and high possibility of overdose.

Injection:
Extremely few reports of injection. Intermuscular and subcutaneous injection is almost guaranteed to result in a abcess. Extremely small < 2mg doses of iv injection reported to result in instant and overwhelming effects.

HARM REDUCTION

Test the drug. This is especially important as 2C-B is often wrongly sold as ecstasy and vice-versa to a lesser extent. More importantly, harmful additives such as methamphetamine, bath salts and PMMA have been found in pills sold as ecstasy and 2C-B. We recommend that you always test your pills using a drug-testing kit.
Don´t take 2-CB if you feel down or depressed.
It is easy to become dehydrated during the experience ensure you have water easily available, be it at home or in a club.
After a 2C-B experience you may have some residual energy leftover which can sometimes cause insomnia.

CRITICAL WARNING

Extreme Caution

Like other serotonergic psychedelics, 2C-x compounds should not be combined with SSRIs (selective serotonin reuptake inhibitors) or tricyclic antidepressants. Mixing these substances can result in serotonin syndrome, a potentially life-threatening condition where excessive serotonin accumulates in the body. This can lead to serious physical and cognitive health issues.

DOSAGE:

Taking a dose higher than 50mg can cause bodily discomfort, nausea and hyperthermia and an all around unpleasant experience.

2c-x Compounds Drug Interactions

5-MeO-xx

The 5-MeO psychedelics can unpredictably potentiate the effects of other psychedelics.

Alcohol

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Be careful when mixing these drugs. While the effects are not likely to be physically harmful, there is a higher chance of experiencing nausea and other unwanted side effects.

Amphetamines

The focusing and anxiogenic effects of stimulants like amphetamines increase the likelihood of unpleasant thought loops. Since psychedelics already have stimulating effects, adding amphetamines is generally unnecessary and can lead to discomfort.

Cocaine

Similar to amphetamines, cocaine can also increase the chances of unpleasant thought loops due to its stimulating and anxiogenic effects. Combining cocaine with psychedelics is usually unnecessary and may cause discomfort.

maois

MAO-B inhibitors can unpredictably increase the potency and duration of phenethylamines.

DMT

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Be careful when mixing these drugs. Effects will compound with each other, however, the effects of DMT will probably overpower that of 2C-B since it is a much more powerful hallucinogen.

NBOMes

NBOMes and NBOHs cause stimulation and vasoconstriction. Their combination with psychedelics, especially those from the 2C-x series, is generally unnecessary and may lead to discomfort.

lithium

Lithium is commonly prescribed for bipolar disorder. Anecdotal evidence shows that combining lithium with psychedelics increases the risk of psychosis and seizures, so this combination is strongly discouraged.

Cannabis

Cannabis can have an unexpectedly strong and unpredictable synergy with 2C-B. This increases the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users should start with a fraction of their usual dose and take breaks to avoid accidental overdose.

stimulants

Stimulants like amphetamines, cocaine, or methylphenidate affect various brain regions and dopaminergic function. This combination can heighten the risk of anxiety, paranoia, panic attacks, and thought loops, and may increase the risk of mania and psychosis.

tramadol

Tramadol is known to lower the seizure threshold, and psychedelics may trigger seizures in susceptible individuals.

opioids

These combinations are considered extremely harmful and should always be avoided. Reactions to combining these drugs are highly unpredictable and can potentially cause death. Tramadol lowers the seizure threshold and thus should not be combined with any psychedelics, MAOIs, amphetamines and substituted amphetamines, or other opioids.

HEALTH CONSIDERATIONS

Toxicity and Long-Term Effects

The toxicity and long-term effects of recreational 2C-B use have not been studied scientifically, and the toxic dose remains unknown. Anecdotal evidence suggests that low to moderate doses or sparing use may not have significant health consequences, although no guarantees can be made. Harm reduction practices are recommended.

Neurotoxicity

Normal doses of 2C-B are considered unlikely to cause neurotoxicity. Based on data extrapolated from rat studies, an estimated toxic dose may range from 330-650 mg. Users should avoid doses of this magnitude to prevent long-term damage, as typical doses are generally considered safe.

Cardiac Risks

Higher doses of 2C-B can cause hypertension, hyperthermia, and tachycardia. Those with pre-existing heart conditions should avoid 2C-B use, and users are advised to monitor their temperature and heart rate. Vigorous physical activity while using 2C-B is discouraged.

Dependence Potential

Like other serotonergic psychedelics, 2C-B is regarded as non-addictive and has a low potential. for misuse. Tolerance does not develop quickly after ingestion, and many anecdotal reports suggest that it can be consumed for several days in a row or through continuous redosing without significant tolerance buildup. There is no cross-tolerance between 2C-B and other serotonergic psychedelics, though the opposite has been observed: other psychedelics can influence 2C-B tolerance. Users generally report that 2C-B's tolerance clock operates independently from other psychedelics.

2C-B | BEES | NEXUS | BROMO MESCALINE

Substance Information Sheet

Novel Psychedelics

Class Membership

ROUTES OF ADMINISTRATION

HARM REDUCTION

CRITICAL WARNING

Extreme Caution

2c-x Compounds Drug Interactions

HEALTH CONSIDERATIONS

Navigating PSYCHEDELIC EXPERIENCES

SET

SETTING

TRIP SITTERS

Special Thanks to

NOTICE

attention:

2C-B | BEES | NEXUS | BROMO MESCALINE

Substance Information Sheet

Novel Psychedelics

Class Membership

ROUTES OF ADMINISTRATION

HARM REDUCTION

CRITICAL WARNING

Extreme Caution

2c-x Compounds Drug Interactions

HEALTH CONSIDERATIONS

Navigating PSYCHEDELIC EXPERIENCES

SET

SETTING

TRIP SITTERS

Special Thanks to

NOTICE

attention:

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