COCAINE | COKE | CHARLIE

• Cocaine is a bitter, numbing powder derived from the leaves of the coca plant, which mainly grows in South America.
• The leaves of the coca plant can be chewed or made into tea. Coca leaves are used this way legally in many countries as a mild stimulant similar to caffeine.
• Until 1929, Coca-Cola contained cocaine (hence the name) and so did many other over-the-counter food and medicine products.
• Cocaine is used in medicine today as a local anaesthetic (numbing agent).
• Crack cocaine is made by heating baking soda with cocaine to make smokeable “rocks.” Crack is, for all intents and purposes, smokeable cocaine.

Combining stimulants with various substances can pose significant health risks:

Psychedelics:

- Mushrooms, LSD, DMT, Mescaline, 2C-x, 5-MeO-xxT: Stimulants increase anxiety and focusing effects, heightening the risk of thought loops, which can lead to negative experiences.

Cannabis: Stimulants can increase anxiety and the likelihood of thought loops, potentially resulting in an unpleasant experience.

Ketamine: Stimulants can raise blood pressure, and high doses increase the risk of physical injury when moving around. 

MXE: Stimulants taken with MXE may easily induce hypermanic states, particularly with sleep deprivation.

Stimulants:

- Amphetamines: Increases strain on the heart. Cocaine may diminish the dopamine-releasing effect of amphetamines.

- MDMA: Cocaine reduces MDMA’s desirable effects but increases the risk of heart attack.

- Caffeine: Both increase the risk of tachycardia, hypertension, and, in extreme cases, heart failure.

GHB and GBL: Stimulants elevate respiration rates, enabling higher sedative doses. If the stimulant wears off first, the sedative can cause respiratory arrest.

DOx: Combined stimulation can cause uncomfortable body effects and thought loops. Coming down from cocaine while DOx is active is anxiogenic.

25x-NBOMe and 2C-T-x: Combination with cocaine can cause severe vasoconstriction, tachycardia, hypertension, and potentially heart failure.

DXM: Both increase heart rate, and panic attacks may cause more serious cardiac issues.

PCP: This combination easily induces hypermanic states.

Alcohol: Stimulants reduce alcohol’s sedative effects, leading to excessive drinking, liver damage, and dehydration. The stimulant-alcohol combination forms cocaethylene, potentiating cocaine.

Opioids: Elevated respiration rates may lead to higher opioid consumption. If the stimulant effect wears off first, the opioid may cause respiratory arrest.

Tramadol: Both stimulants and tramadol increase the risk of seizures.

MAOIs: This combination has not been well-researched and could be unpredictable.