Drugs.com lists 369 moderate and 28 major prescription drug interactions. If you are on prescription meds it might be a good idea to check if they interact with cannabis, try the drugs.com interaction checker tool here.
⚠️ Caution ⚠️
These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
2C-T-X
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
2C-X
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
5-MEO-XXT
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Amphetamines
Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
AMT
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics. Small amounts can reduce nausea with aMT but take care.
Cocaine
Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
DMT
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
DOX
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
LSD
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Mescaline
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Mushrooms
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
NBOMES
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
↗ Low Risk & Synergy ↗
These drugs work together to cause an effect greater than the sum of its parts, and they aren't likely to cause an adverse or undesirable reaction when used carefully. Additional research should always be done before combining drugs.
Alcohol
In excess, this combination can cause nausea.
Dextromethorphan
GHB/GBL
Ketamine
MAOIS
MDMA
Large amounts of cannabis may cause strong and somewhat unpredictable experiences in combination with MDMA. Cannabis should be saved for towards the end of the experience if possible.
MXE
Nitrous
Opioids
PCP
Tramadol
➡ Low Risk & No Synergy ➡
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
Caffeine
SSRIS
↘ Low Risk & Decrease ↘
Effects are subtractive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
Benzodiazepines